Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 14/20 | 0.56 |
| ▸ | BRAF | P15056 | 6/20 | 0.56 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.54 |
| ▸ | PLK4 | O00444 | 1/20 | 0.54 |
| ▸ | PIR | O00625 | 1/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.54 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.54 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.54 |
| ▸ | STK16 | O75716 | 1/20 | 0.54 |
| ▸ | OXSR1 | O95747 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
| ▸ | RAF1 | P04049 | 1/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | FYN | P06241 | 1/20 | 0.54 |
| ▸ | FES | P07332 | 1/20 | 0.54 |
| ▸ | CSF1R | P07333 | 1/20 | 0.54 |
| ▸ | YES1 | P07947 | 1/20 | 0.54 |
| ▸ | LYN | P07948 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30866274 | 0.85 | BRAF (0.57) | BRAF | |
| SCHEMBL21223003 | 0.84 | BRAF (0.58) | MAP2K4BRAFBMPR1BPLK4PIR | |
| SCHEMBL21223018 | 0.84 | MAP2K4 (0.75) | MAP2K4BRAFRIPK2RAF1KDR | |
| SCHEMBL30636752 | 0.84 | MAP2K4 (0.75) | MAP2K4BRAFRIPK2RAF1KDR | |
| SCHEMBL29796856 | 0.83 | BRAF (0.74) | MAP2K4BRAFBMPR1BPLK4PIR | |
| SCHEMBL298039 | 0.83 | BRAF (0.74) | MAP2K4BRAFBMPR1BPLK4PIR | |
| SCHEMBL23098863 | 0.82 | MAP2K4 (0.75) | MAP2K4BRAFRIPK2RAF1KDR | |
| SCHEMBL21224028 | 0.82 | MAP2K4 (0.66) | MAP2K4BRAFRIPK2RAF1KDR | |
| SCHEMBL30694412 | 0.82 | MAP2K4 (0.66) | MAP2K4BRAFRIPK2RAF1KDR | |
| SCHEMBL30694413 | 0.82 | MAP2K4 (0.75) | MAP2K4BRAFRIPK2RAF1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427433-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | Plexxikon, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |