Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fexofenadine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 4/20 | 0.66 |
| ▸ | LMNA | P02545 | 4/20 | 0.66 |
| ▸ | DRD3 | P35462 | 3/20 | 0.66 |
| ▸ | DRD2 | P14416 | 2/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.65 |
| ▸ | HTR2A | P28223 | 3/20 | 0.65 |
| ▸ | HTR2B | P41595 | 2/20 | 0.65 |
| ▸ | BLM | P54132 | 2/20 | 0.65 |
| ▸ | CNR1 | P21554 | 2/20 | 0.65 |
| ▸ | APEX1 | P27695 | 1/20 | 0.65 |
| ▸ | PDE4A | P27815 | 1/20 | 0.65 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.65 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.53 |
| ▸ | CYP2J2 | P51589 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fexofenadine SCHEMBL6382541 | 0.83 | HRH1 (0.96) | LMNAHRH1DRD3DRD2ALOX15 | |
| Fexofenadine SCHEMBL6382537 | 0.83 | HRH1 (0.96) | LMNAHRH1DRD3DRD2ALOX15 | |
| Fexofenadine SCHEMBL40914 | 0.81 | HRH1 (1.00) | LMNAHRH1DRD3DRD2ALOX15 | |
| Fexofenadine SCHEMBL40915 | 0.81 | HRH1 (1.00) | LMNAHRH1DRD3DRD2ALOX15 | |
| Fexofenadine SCHEMBL29562068 | 0.81 | HRH1 (1.00) | LMNAHRH1DRD3DRD2ALOX15 | |
| Fexofenadine SCHEMBL1395627 | 0.81 | HRH1 (0.98) | LMNAHRH1DRD3DRD2ALOX15 | |
| Fexofenadine SCHEMBL3543634 | 0.81 | HRH1 (0.98) | LMNAHRH1DRD3DRD2ALOX15 | |
| Fexofenadine SCHEMBL48729 | 0.81 | HRH1 (0.98) | LMNAHRH1DRD3DRD2ALOX15 | |
| Fexofenadine SCHEMBL1972366 | 0.81 | HRH1 (1.00) | LMNAHRH1DRD3DRD2ALOX15 | |
| Fexofenadine SCHEMBL1561082 | 0.81 | HRH1 (1.00) | LMNAHRH1DRD3DRD2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427178-A2 | DERMAL DELIVERY COMPOSITIONS COMPRISING ACTIVE AGENT-CALCIUM PHOSPHATE PARTICLE COMPLEXES AND METHODS OF USING THE SAME | Laboratory Skin Care, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010129819-A2 | DERMAL DELIVERY COMPOSITIONS COMPRISING ACTIVE AGENT-CALCIUM PHOSPHATE PARTICLE COMPLEXES AND METHODS OF USING THE SAME | LABORATORY SKIN CARE, INC. (US) | 2010-11-11 | — | — | WO | disclosed |