Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.60 |
| ▸ | BRAF | P15056 | 8/20 | 0.58 |
| ▸ | RAF1 | P04049 | 5/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.58 |
| ▸ | HIPK4 | Q8NE63 | 4/20 | 0.57 |
| ▸ | MET | P08581 | 2/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.56 |
| ▸ | PLK4 | O00444 | 2/20 | 0.56 |
| ▸ | AURKA | O14965 | 2/20 | 0.56 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.56 |
| ▸ | ABL1 | P00519 | 2/20 | 0.56 |
| ▸ | LCK | P06239 | 2/20 | 0.56 |
| ▸ | FYN | P06241 | 2/20 | 0.56 |
| ▸ | LYN | P07948 | 2/20 | 0.56 |
| ▸ | RET | P07949 | 2/20 | 0.56 |
| ▸ | SRC | P12931 | 2/20 | 0.56 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.56 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.56 |
| ▸ | AXL | P30530 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26921831 | 1.00 | KDR (0.60) | KDRBRAFRAF1EPHX2HIPK4 | |
| SCHEMBL26922321 | 0.92 | KDR (0.60) | KDRBRAFRAF1EPHX2HIPK4 | |
| SCHEMBL26921440 | 0.92 | KDR (0.60) | KDRBRAFRAF1EPHX2HIPK4 | |
| SCHEMBL26921897 | 0.92 | KDR (0.64) | KDRBRAFRAF1EPHX2HIPK4 | |
| SCHEMBL27173866 | 0.91 | KDR (0.62) | KDRBRAFRAF1EPHX2HIPK4 | |
| SCHEMBL29834896 | 0.91 | KDR (0.62) | KDRBRAFRAF1EPHX2HIPK4 | |
| SCHEMBL26922066 | 0.91 | HIPK4 (0.69) | KDRBRAFRAF1EPHX2HIPK4 | |
| SCHEMBL29834890 | 0.90 | HIPK4 (0.61) | KDRBRAFRAF1EPHX2HIPK4 | |
| SCHEMBL29834835 | 0.90 | KDR (0.57) | KDRBRAFRAF1EPHX2HIPK4 | |
| SCHEMBL26922708 | 0.90 | KDR (0.57) | KDRBRAFRAF1EPHX2HIPK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4288539-A1 | COMPOSITIONS AND METHODS FOR TREATING DISEASE ASSOCIATED WITH DUX4 OVEREXPRESSION | Research Institute at Nationwide Children's Hospital (US) | 2023-12-13 | — | — | EP | disclosed |
| WO-2022169922-A1 | COMPOSITIONS AND METHODS FOR TREATING DISEASE ASSOCIATED WITH DUX4 OVEREXPRESSION | RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (US) | 2022-08-11 | — | — | WO | disclosed |