HIPK4 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL232042	1.00	6/20
SCHEMBL234334	1.00	5/20
SCHEMBL421841	0.79	5/20
SCHEMBL421486	0.64	5/20
SCHEMBL422705	0.63	5/20
SCHEMBL423233	0.63	5/20
SCHEMBL422546	0.59	5/20
SCHEMBL422916	0.58	5/20
SCHEMBL422865	1.00	4/20
SCHEMBL419413	0.81	4/20
SCHEMBL421214	0.81	4/20
SCHEMBL420822	0.80	4/20
SCHEMBL419044	0.79	4/20
SCHEMBL422803	0.78	4/20
SCHEMBL420726	0.78	4/20
SCHEMBL422104	0.78	4/20
SCHEMBL423038	0.78	4/20
SCHEMBL422817	0.74	4/20
SCHEMBL421811	0.67	4/20
SCHEMBL147422	0.66	4/20

Clinical trials — most relevant to HIPK4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus	PHASE3	UNKNOWN
Study in Adult Ph-positive ALL	PHASE2	UNKNOWN
Alrizomadlin (APG-115) in Subjects With BAP1 Cancer Syndrome and Early-Stage Mesothelioma	PHASE2	WITHDRAWN
PhII 5-Azacytidine Plus Valproic Acid and Eventually Atra in Intermediate II and High Risk MDS	PHASE2	COMPLETED
A Phase II Study of Bevacizumab and Erlotinib in Subjects With Advanced Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) or Sporadic Papillary Renal Cell Cancer	PHASE2	COMPLETED
Study of the Beach Regimen on Relapsed/Refractory Acute Myeloid Leukemia (R/R AML)	PHASE2	ACTIVE_NOT_RECRUITING
Treatment Duration Increment and Pharmacodynamic Study of CX-4945 in Patients With Basal Cell Carcinoma (BCC)	PHASE1	COMPLETED
FOLFIRINOX Plus IPI-926 for Advanced Pancreatic Adenocarcinoma	PHASE1	COMPLETED
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma	PHASE1	COMPLETED
PHF19 Gene Expression and EZH2 Gene Deletion in Acute Myeloid Leukemia	nan	UNKNOWN
Investigation of the HDAC4 Copy Number Variation and Its Effect on Gene and Protein Expression in Patients With ASD	nan	COMPLETED
HE4 is a Beneficial Biomarker in Endometrial Cancer	nan	UNKNOWN
The PAH Platform for Deep Phenotyping in Korean Subjects	nan	UNKNOWN
Evaluating the Relationship of Morphine Consumption and Pain-related Molecules in Hepatic Surgical Patients	nan	COMPLETED
Genetic Mechanisms and Additional Risk Factors Underlying Hip Dysplasia	nan	COMPLETED
Epithelioid Haemangioendothelioma Observational Study	nan	RECRUITING
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA	nan	RECRUITING
Use of miRNAs in Growth Hormone Deficiency (GHD)	nan	UNKNOWN
Analyzing Gene Regions That May Interact With the Effectiveness of High Blood Pressure Drugs	nan	WITHDRAWN
Clinical and Genetic Analysis in Congenital Hypothyroidism Due to Thyroid Dysgenesis.	nan	COMPLETED
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
Susceptibility Genes in Autism Spectrum Disorders	nan	COMPLETED
Study of Metabolic Modifications in Children With Noonan Syndrome	nan	COMPLETED
Genes Associated With Development of Pulmonary Arterial Hypertension in Patients With Congenital Shunt Lesions	nan	RECRUITING
Effect of Exercise on the Human Skeletal Muscle Phosphoproteome	nan	COMPLETED
Ischemic Preconditioning - Perspectives of Use Vivio/in Vitro Studies	nan	ENROLLING_BY_INVITATION
Efficacy of Cognitive Rehabilitation Using Virtual Reality and Computer-based Cognitive Stimulation on Cognitive Impairment Associated to Movement Disorders	nan	COMPLETED
Diaphragmatic Hernia Research & Exploration, Advancing Molecular Science	nan	RECRUITING
Gene Mutations and Rescue in Human Congenital Diaphragmatic Hernia	nan	UNKNOWN
Global Profiling of Gene and Protein Expression Associated With Coronary Heart Disease Reversal	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a HIPK4 binder may also engage these)

Protein	Name	Similarity
Q8WP28	—	0.999	Q8WP28 →
Q3V016	—	0.995	Q3V016 →
Q4V793	—	0.993	Q4V793 →
DYRK1B	Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0.992	landscape →
Q9Z188	—	0.990	Q9Z188 →
Q8C0X8	—	0.987	Q8C0X8 →
Q68UT7	—	0.986	Q68UT7 →
SIK1	Serine/threonine-protein kinase SIK1	0.986	landscape →
Q9Z2A6	—	0.986	Q9Z2A6 →
Q3UIZ8	—	0.986	Q3UIZ8 →
Q60670	—	0.985	Q60670 →
Q66HE5	—	0.985	Q66HE5 →
Q8BWQ5	—	0.985	Q8BWQ5 →
O70551	—	0.985	O70551 →
Q60700	—	0.985	Q60700 →
Q9R0A5	—	0.985	Q9R0A5 →
Q8BZN4	—	0.984	Q8BZN4 →
Q4R739	—	0.984	Q4R739 →
Q924U5	—	0.984	Q924U5 →
Q8R2S1	—	0.984	Q8R2S1 →
Q80Y86	—	0.983	Q80Y86 →
Q63553	—	0.983	Q63553 →
Q8K330	—	0.983	Q8K330 →
Q2KIP2	—	0.983	Q2KIP2 →
O88831	—	0.983	O88831 →
Q9R1U5	—	0.983	Q9R1U5 →
DYRK4	Dual specificity tyrosine-phosphorylation-regulated kinase 4	0.983	landscape →
Q76I79	—	0.983	Q76I79 →
CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2	0.983	landscape →
Q3ULB5	—	0.983	Q3ULB5 →