Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.55 |
| ▸ | VNN1 | O95497 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | AKT1 | P31749 | 1/20 | 0.50 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.49 |
| ▸ | CD38 | P28907 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.45 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.45 |
| ▸ | STAT6 | P42226 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26922246 | 1.00 | RPS6KB1 (0.55) | RPS6KB1VNN1HDAC3HDAC1HDAC2 | |
| SCHEMBL26923596 | 0.83 | CYP2C9 (0.49) | VNN1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL26922081 | 0.83 | KDM4E (0.51) | RPS6KB1VNN1AKT1AURKAAPP | |
| SCHEMBL29834817 | 0.83 | RPS6KB1 (0.55) | RPS6KB1AKT1CD38AURKAKDR | |
| SCHEMBL26923799 | 0.83 | RPS6KB1 (0.55) | RPS6KB1AKT1CD38AURKAKDR | |
| SCHEMBL26921026 | 0.81 | RPS6KB1 (0.60) | RPS6KB1VNN1HDAC3HDAC1HDAC2 | |
| SCHEMBL29834915 | 0.80 | EGFR (0.52) | RPS6KB1AURKAEGFRNPC1 | |
| SCHEMBL26921317 | 0.80 | EGFR (0.52) | RPS6KB1AURKAEGFRNPC1 | |
| SCHEMBL29834798 | 0.79 | RPS6KB1 (0.48) | RPS6KB1VNN1HDAC3HDAC1HDAC2 | |
| SCHEMBL26921856 | 0.79 | RPS6KB1 (0.48) | RPS6KB1VNN1HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4288539-A1 | COMPOSITIONS AND METHODS FOR TREATING DISEASE ASSOCIATED WITH DUX4 OVEREXPRESSION | Research Institute at Nationwide Children's Hospital (US) | 2023-12-13 | — | — | EP | disclosed |
| WO-2022169922-A1 | COMPOSITIONS AND METHODS FOR TREATING DISEASE ASSOCIATED WITH DUX4 OVEREXPRESSION | RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (US) | 2022-08-11 | — | — | WO | disclosed |