Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 6/20 | 0.55 |
| ▸ | AURKA | O14965 | 5/20 | 0.55 |
| ▸ | CD38 | P28907 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | AKT2 | P31751 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29834817 | 1.00 | RPS6KB1 (0.55) | RPS6KB1AURKACD38FFAR1TSHR | |
| SCHEMBL26923596 | 0.85 | CYP2C9 (0.49) | KDRALDH1A1FLT1 | |
| SCHEMBL26922246 | 0.83 | RPS6KB1 (0.55) | RPS6KB1AURKACD38KDRAURKB | |
| SCHEMBL29834918 | 0.83 | RPS6KB1 (0.55) | RPS6KB1AURKACD38KDRAURKB | |
| SCHEMBL26922526 | 0.80 | AURKA (0.51) | RPS6KB1AURKA | |
| SCHEMBL26921354 | 0.79 | KMT2A (0.52) | FFAR1KDRSMN1; SMN2ALDH1A1 | |
| SCHEMBL26922081 | 0.79 | KDM4E (0.51) | RPS6KB1AURKAROCK2MAP4K4AKT1 | |
| SCHEMBL29834838 | 0.78 | RPS6KB1 (0.50) | RPS6KB1AURKACD38FFAR1AURKB | |
| SCHEMBL26921049 | 0.78 | RPS6KB1 (0.50) | RPS6KB1AURKACD38FFAR1AURKB | |
| SCHEMBL26921563 | 0.77 | AURKA (0.55) | RPS6KB1AURKACD38FFAR1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240093191-A1 | COMPOSITIONS AND METHODS FOR TREATING DISEASE ASSOCIATED WITH DUX4 OVEREXPRESSION | RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL (US) | 2024-03-21 | — | — | US | disclosed |
| EP-4288539-A1 | COMPOSITIONS AND METHODS FOR TREATING DISEASE ASSOCIATED WITH DUX4 OVEREXPRESSION | Research Institute at Nationwide Children's Hospital (US) | 2023-12-13 | — | — | EP | disclosed |