Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | STS | P08842 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3882527 | 1.00 | ESR2 (0.50) | ESR2MEN1KMT2ANR1H2HDAC1 | |
| SCHEMBL3872743 | 0.84 | ESR2 (0.49) | ESR2MEN1KMT2ANR1H2HDAC1 | |
| SCHEMBL29835127 | 0.84 | ESR2 (0.49) | ESR2MEN1KMT2ANR1H2HDAC1 | |
| SCHEMBL3874348 | 0.82 | ABHD6 (0.50) | ESR2NR1H2HDAC1DDB1CRBN | |
| SCHEMBL17898122 | 0.81 | NR1H2 (0.48) | ESR2MEN1KMT2ANR1H2HDAC1 | |
| SCHEMBL3878152 | 0.80 | ESR2 (0.49) | ESR2MEN1KMT2ANR1H2HDAC1 | |
| SCHEMBL15503196 | 0.79 | NR1H2 (0.47) | ESR2MEN1KMT2ANR1H2HDAC1 | |
| SCHEMBL3873647 | 0.79 | ESR2 (0.48) | ESR2MEN1KMT2ANR1H2HDAC1 | |
| SCHEMBL3878070 | 0.79 | ESR2 (0.45) | ESR2MEN1KMT2ANR1H2HDAC1 | |
| SCHEMBL8223384 | 0.79 | ESR2 (0.60) | ESR2MEN1KMT2ANR1H2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115052596-B | ADAMTS inhibitor, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2024-06-14 | — | — | CN | disclosed |
| CN-115052596-A | ADAMTS inhibitor, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2022-09-13 | — | — | CN | disclosed |