Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | GHSR | Q92847 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | GCK | P35557 | 1/20 | 0.31 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23762270 | 1.00 | NR1H2 (0.34) | NR1H2ACACBJAK2JAK3PTK2 | |
| SCHEMBL23762272 | 0.93 | ACACB (0.33) | NR1H2ACACBJAK2JAK3PTK2 | |
| SCHEMBL23751229 | 0.93 | MAPT (0.34) | MAPTKDM4EALDH1A1HPGDTSHR | |
| SCHEMBL23762097 | 0.91 | ACHE (0.39) | NR1H2ACACBJAK2JAK3PTK2 | |
| SCHEMBL23751127 | 0.89 | NR1H2 (0.37) | NR1H2ACACBJAK2JAK3PTK2 | |
| SCHEMBL29836527 | 0.87 | NR1H2 (0.41) | NR1H2ACACBJAK2JAK3PTK2 | |
| SCHEMBL23762208 | 0.87 | NR1H2 (0.41) | NR1H2ACACBJAK2JAK3PTK2 | |
| SCHEMBL23762188 | 0.87 | KDM4E (0.38) | NR1H2ACACBMAPTKDM4EALDH1A1 | |
| SCHEMBL23751196 | 0.85 | NR1H2 (0.36) | NR1H2ACACBJAK2JAK3PTK2 | |
| SCHEMBL23762199 | 0.83 | NR1H2 (0.40) | NR1H2ACACBJAK2JAK3PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3807273-B1 | AZAINDOLE DERIVATIVES AS RHO-KINASE INHIBITORS | CHIESI FARM SPA (IT) | 2022-08-03 | — | — | EP | disclosed |