Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | GLS | O94925 | 4/20 | 0.48 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24846111 | 1.00 | KMT2A (0.48) | KMT2AMEN1GLSDGAT1NPC1 | |
| SCHEMBL24846113 | 1.00 | KMT2A (0.48) | KMT2AMEN1GLSDGAT1NPC1 | |
| SCHEMBL24846684 | 1.00 | KMT2A (0.48) | KMT2AMEN1GLSDGAT1NPC1 | |
| SCHEMBL24846403 | 0.90 | DGAT1 (0.41) | KMT2AMEN1GLSDGAT1NPC1 | |
| SCHEMBL24846718 | 0.90 | DGAT1 (0.41) | KMT2AMEN1GLSDGAT1NPC1 | |
| SCHEMBL24846402 | 0.90 | DGAT1 (0.41) | KMT2AMEN1GLSDGAT1NPC1 | |
| SCHEMBL24846712 | 0.89 | KMT2A (0.47) | KMT2AMEN1GLSDGAT1NPC1 | |
| SCHEMBL24846719 | 0.89 | KMT2A (0.47) | KMT2AMEN1GLSDGAT1NPC1 | |
| SCHEMBL24847734 | 0.89 | KMT2A (0.47) | KMT2AMEN1GLSDGAT1NPC1 | |
| SCHEMBL24846609 | 0.86 | RXFP1 (0.38) | KMT2AMEN1GLSDGAT1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4055011-A1 | MRGPRX2 ANTAGONISTS AND USES THEREOF | Dermira, Inc (US) | 2022-09-14 | — | — | EP | disclosed |