Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 7/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 12/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 11/20 | 0.38 |
| ▸ | KRAS | P01116 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27186150 | 1.00 | SOS1 (0.38) | SOS1ROCK1ROCK2KRASMEN1 | |
| SCHEMBL27186155 | 1.00 | SOS1 (0.38) | SOS1ROCK1ROCK2KRASMEN1 | |
| SCHEMBL29843929 | 0.82 | ROCK1 (0.40) | SOS1ROCK1ROCK2 | |
| SCHEMBL27187060 | 0.82 | ROCK1 (0.40) | SOS1ROCK1ROCK2 | |
| SCHEMBL27187054 | 0.82 | ROCK1 (0.40) | SOS1ROCK1ROCK2 | |
| SCHEMBL27186124 | 0.76 | KRAS (0.35) | SOS1ROCK1ROCK2KRASMEN1 | |
| SCHEMBL27186119 | 0.76 | KRAS (0.35) | SOS1ROCK1ROCK2KRASMEN1 | |
| SCHEMBL29844200 | 0.72 | SOS1 (0.42) | SOS1KRAS | |
| SCHEMBL27186192 | 0.72 | ALDH1A1 (0.34) | MEN1LMNAPOLBHTTKMT2A | |
| SCHEMBL27186224 | 0.72 | ROCK1 (0.43) | SOS1ROCK1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117651701-A | Novel substituted bicyclic aza heterocycles as SOS1 inhibitors | 唯久生物技术(苏州)有限公司 | 2024-03-05 | — | — | CN | disclosed |
| WO-2022187266-A1 | NOVEL SUBSTITUTED BICYCLI AZA-HETEROCYCLES AS SOS1 INHIBITORS | VIVA STAR BIOSCIENCES (SUZHOU) CO., LTD. (CN) | 2022-09-09 | — | — | WO | disclosed |