Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | UGCG | Q16739 | 1/20 | 0.34 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | TACR1 | P25103 | 2/20 | 0.31 |
| ▸ | ALPL | P05186 | 2/20 | 0.31 |
| ▸ | GHSR | Q92847 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.30 |
| ▸ | PDE2A | O00408 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23753820 | 1.00 | FFAR1 (0.35) | FFAR1UGCGTRPC5GPBAR1PSEN1 | |
| SCHEMBL29847050 | 0.90 | HSD17B13 (0.34) | ALPLKCNN4PDE2A | |
| SCHEMBL22470689 | 0.90 | HSD17B13 (0.34) | ALPLKCNN4PDE2A | |
| SCHEMBL29847281 | 0.84 | TRPV1 (0.37) | FFAR1UGCGPSEN1PSEN2APH1B | |
| SCHEMBL23753929 | 0.84 | PDE2A (0.33) | GPBAR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL29846857 | 0.84 | PDE2A (0.33) | GPBAR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL23761249 | 0.79 | GPR55 (0.36) | KCNH2GABRG2GABRB3GABRA5BRD4 | |
| SCHEMBL23753835 | 0.79 | PIK3CG (0.37) | FFAR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL29847002 | 0.79 | PIK3CG (0.37) | FFAR1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL23753939 | 0.78 | KCNN4 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115135648-B | Dihydronaphthyridones, preparation method and medical application thereof | 劲方医药科技(上海)有限公司 | 2024-02-09 | — | — | CN | disclosed |
| CN-115135648-A | Dihydronaphthyridinone compounds, preparation method and medical application thereof | 劲方医药科技(上海)有限公司 | 2022-09-30 | — | — | CN | disclosed |