Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 14/20 | 0.48 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29177117 | 0.80 | MAPT (0.50) | PDE1BP2RX4MAPTTHRBPDE5A | |
| SCHEMBL30061820 | 0.80 | MAPT (0.50) | PDE1BP2RX4MAPTTHRBPDE5A | |
| SCHEMBL29918643 | 0.73 | ADORA1 (0.43) | MAPTALDH1A1CYP1A2CYP3A4HPGD | |
| SCHEMBL24671864 | 0.73 | ADORA1 (0.43) | MAPTALDH1A1CYP1A2CYP3A4HPGD | |
| SCHEMBL25241170 | 0.70 | PDE1B (0.57) | PDE1BPDE5AUSP2ALDH1A1CYP1A2 | |
| SCHEMBL5871817 | 0.69 | MAPT (0.61) | P2RX4MAPTTHRBALDH1A1SMN1; SMN2 | |
| SCHEMBL31138328 | 0.68 | PDE5A (0.54) | P2RX4MAPTTHRBPDE5AALDH1A1 | |
| SCHEMBL24138327 | 0.68 | PDE5A (0.54) | P2RX4MAPTTHRBPDE5AALDH1A1 | |
| SCHEMBL13737524 | 0.68 | P2RX4 (0.59) | P2RX4MAPTPDE5AALDH1A1TSHR | |
| SCHEMBL16627606 | 0.68 | P2RX4 (0.59) | P2RX4MAPTPDE5AALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116669738-A | Pyrimidopyridone derivative as SOS1 inhibitor, and preparation method and application thereof | 苏州阿尔脉生物科技有限公司 | 2023-08-29 | — | — | CN | disclosed |
| WO-2022170802-A1 | PYRIMIDO-PYRIDONE DERIVATIVE AS SOS1 INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 苏州阿尔脉生物科技有限公司 | 2022-08-18 | — | — | WO | disclosed |