Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.59 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.59 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.56 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.49 |
| ▸ | GRIA1 | P42261 | 6/20 | 0.48 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.48 |
| ▸ | AOC2 | O75106 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | TDP2 | O95551 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.42 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.42 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7076084 | 0.82 | GRIA1 (0.63) | PDE3BPDE3ACYP11B2CYP11B1CYP1A2 | |
| SCHEMBL29849879 | 0.80 | GRIA1 (0.67) | PDE3BPDE3ACYP11B2CYP11B1CYP1A2 | |
| SCHEMBL26463255 | 0.80 | GRIA1 (0.67) | PDE3BPDE3ACYP11B2CYP11B1CYP1A2 | |
| SCHEMBL29850035 | 0.77 | PDE3B (0.60) | PDE3BPDE3ACYP11B2CYP11B1CYP1A2 | |
| SCHEMBL23143482 | 0.75 | PDE3B (1.00) | PDE3BPDE3ACYP11B2CYP11B1CYP1A2 | |
| SCHEMBL31139508 | 0.72 | GRIA1 (0.50) | PDE3BPDE3ACYP11B2CYP11B1CYP1A2 | |
| SCHEMBL29899595 | 0.72 | CYP11B1 (1.00) | PDE3BPDE3ACYP11B2CYP11B1CYP1A2 | |
| SCHEMBL29849827 | 0.72 | CYP11B1 (1.00) | PDE3BPDE3ACYP11B2CYP11B1CYP1A2 | |
| SCHEMBL748904 | 0.72 | CYP11B1 (1.00) | PDE3BPDE3ACYP11B2CYP11B1CYP1A2 | |
| SCHEMBL29849907 | 0.72 | CYP11B1 (1.00) | PDE3BPDE3ACYP11B2CYP11B1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4034526-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | Agency for Science, Technology and Research (A*STAR) (SG) | 2022-08-03 | — | — | EP | disclosed |