Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 2/20 | 0.63 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.63 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.55 |
| ▸ | PGR | P06401 | 3/20 | 0.50 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 2/20 | 0.49 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.48 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.47 |
| ▸ | TDP2 | O95551 | 2/20 | 0.47 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.45 |
| ▸ | AHR | P35869 | 2/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29849809 | 0.82 | PDE3B (0.59) | GRIA1CACNG8PGRPDE3BPDE3A | |
| SCHEMBL10712809 | 0.80 | GRIA1 (0.69) | GRIA1CACNG8PGRPDE3BPDE3A | |
| SCHEMBL21517844 | 0.78 | PGR (0.56) | GRIA1CACNG8PGRPDE3BPDE3A | |
| SCHEMBL21517849 | 0.78 | GRIA1 (0.62) | GRIA1CACNG8PGRPDE3BPDE3A | |
| SCHEMBL21483771 | 0.78 | GRIA1 (0.66) | GRIA1CACNG8PGRPDE3BPDE3A | |
| SCHEMBL24884440 | 0.77 | GRIA1 (0.69) | GRIA1CACNG8PGRPDE3BPDE3A | |
| SCHEMBL10714302 | 0.77 | GRIA1 (1.00) | GRIA1CACNG8PGRPDE3BPDE3A | |
| SCHEMBL28639586 | 0.77 | GRIA1 (0.69) | GRIA1CACNG8PGRPDE3BPDE3A | |
| SCHEMBL29849951 | 0.77 | CRBN (0.51) | GRIA1CACNG8CHEK1BRD4CREBBP | |
| SCHEMBL29899624 | 0.77 | TDP2 (0.72) | GRIA1CACNG8PGRPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294688-A2 | INDOLINONE DERIVATIVES AS PROTEIN KINASE/PHOSPHATASE INHIBITORS | Sugen, Inc. (US) | 2003-03-26 | — | — | EP | claimed |
| WO-2001094312-A2 | INDOLINONE DERIVATIVES AS PROTEIN KINASE/PHOSPHATASE INHIBITORS | SUGEN, INC. (US) | 2001-12-13 | — | — | WO | claimed |