Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | F2RL3 | Q96RI0 | 2/20 | 0.36 |
| ▸ | CFD | P00746 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23218814 | 1.00 | TSHR (0.39) | TSHRKDM4EALDH1A1HPGDGAA | |
| SCHEMBL23218071 | 0.92 | F2RL3 (0.37) | KDM4EGAAF2RL3PDE10APOLB | |
| SCHEMBL23218130 | 0.88 | TSHR (0.39) | TSHRKDM4EALDH1A1HPGDGAA | |
| SCHEMBL23218399 | 0.87 | TSHR (0.41) | TSHRKDM4EALDH1A1HPGDGAA | |
| SCHEMBL29852645 | 0.87 | TSHR (0.41) | TSHRKDM4EALDH1A1HPGDGAA | |
| SCHEMBL29852791 | 0.86 | CFD (0.43) | TSHRKDM4EALDH1A1HPGDGAA | |
| SCHEMBL23218533 | 0.86 | CFD (0.43) | TSHRKDM4EALDH1A1HPGDGAA | |
| SCHEMBL23218232 | 0.84 | TSHR (0.40) | TSHRKDM4EALDH1A1HPGDGAA | |
| SCHEMBL23218205 | 0.84 | TSHR (0.40) | TSHRKDM4EALDH1A1HPGDGAA | |
| SCHEMBL29852953 | 0.84 | TSHR (0.40) | TSHRKDM4EALDH1A1HPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4041238-A1 | ORAL COMPLEMENT FACTOR D INHIBITORS | Biocryst Pharmaceuticals, Inc. (US) | 2022-08-17 | — | — | EP | disclosed |