Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 6/20 | 0.68 |
| ▸ | ABL1 | P00519 | 12/20 | 0.55 |
| ▸ | SRC | P12931 | 2/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.55 |
| ▸ | KDR | P35968 | 2/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | RET | P07949 | 1/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.55 |
| ▸ | BRAF | P15056 | 1/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.55 |
| ▸ | FLT1 | P17948 | 1/20 | 0.55 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.55 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.55 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.55 |
| ▸ | JAK1 | P23458 | 1/20 | 0.55 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.55 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22288302 | 1.00 | KIT (0.68) | KITABL1SRCFGFR1KDR | |
| SCHEMBL29856255 | 0.93 | KIT (0.78) | KITABL1FGFR1KDRBRAF | |
| SCHEMBL16755338 | 0.93 | KIT (0.78) | KITABL1FGFR1KDRBRAF | |
| SCHEMBL16755299 | 0.88 | KIT (0.87) | KITABL1SRCFGFR1KDR | |
| SCHEMBL28439198 | 0.84 | KIT (0.79) | KITABL1FGFR1KDRBRAF | |
| SCHEMBL29856195 | 0.84 | KIT (0.79) | KITABL1FGFR1KDRBRAF | |
| SCHEMBL13813508 | 0.82 | KIT (0.77) | KITABL1FGFR1KDRBRAF | |
| SCHEMBL22300440 | 0.81 | KIT (0.61) | KITABL1FGFR1KDRRET | |
| SCHEMBL22300432 | 0.81 | KIT (0.61) | KITABL1FGFR1KDRRET | |
| SCHEMBL28441871 | 0.81 | KIT (0.61) | KITABL1FGFR1KDRRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111484482-B | Alkynyl pyrimidine or alkynyl pyridine compound, and composition and application thereof | 北京赛特明强医药科技有限公司 | 2022-06-21 | — | — | CN | disclosed |