SCHEMBL29856299

SCHEMBL29856299

CCc1c(C(=O)c2ccc(OCc3ccccc3)cc2)c2cccnc2n1C

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.49
SRD5A2 P31213 1/20 0.49
ALDH1A1 P00352 2/20 0.47
HTT P42858 2/20 0.47
GAA P10253 1/20 0.47
MAPT P10636 1/20 0.47
RAB9A P51151 1/20 0.47
MAOB P27338 1/20 0.47
PARP10 Q53GL7 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.46
NR4A1 P22736 1/20 0.46
NR4A2 P43354 1/20 0.46
NR4A3 Q92570 1/20 0.46
NR1H4 Q96RI1 2/20 0.46
CYP19A1 P11511 1/20 0.45
CYP11B1 P15538 1/20 0.45
CYP11B2 P19099 1/20 0.45
PPARG P37231 3/20 0.45
SLC6A7 Q99884 1/20 0.44
RXRA P19793 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29856151 0.86 MAOB (0.51) SMN1; SMN2SRD5A2ALDH1A1HTTGAA
SCHEMBL29856222 0.85 SRD5A2 (0.47) SMN1; SMN2SRD5A2ALDH1A1HTTGAA
SCHEMBL29856238 0.84 SLC22A12 (0.43) HDAC3HDAC1HDAC2EGFR
SCHEMBL29856204 0.83 SRD5A2 (0.49) SMN1; SMN2SRD5A2ALDH1A1HTTGAA
SCHEMBL29856187 0.81 SRD5A2 (0.47) SMN1; SMN2SRD5A2ALDH1A1HTTGAA
SCHEMBL29856194 0.81 SRD5A2 (0.47) SMN1; SMN2SRD5A2ALDH1A1HTTGAA
SCHEMBL29856292 0.80 SRD5A2 (0.46) SMN1; SMN2SRD5A2ALDH1A1HTTGAA
SCHEMBL29856328 0.78 MEN1 (0.46) SMN1; SMN2SRD5A2ALDH1A1HTTGAA
SCHEMBL29856130 0.75 SMN1; SMN2 (0.50) SMN1; SMN2SRD5A2ALDH1A1HTTGAA
SCHEMBL29856249 0.75 SRD5A2 (0.47) SMN1; SMN2SRD5A2ALDH1A1HTTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022169974-A1 INHIBITORS OF URAT1 AND PHARMACEUTICAL USES THEREOF NEXYS THERAPEUTICS, INC. (US) 2022-08-11 WO disclosed