Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | GSK3B | P49841 | 3/20 | 0.44 |
| ▸ | CETP | P11597 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KDM6B | O15054 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16303157 | 0.86 | MDM4 (0.46) | MDM4TP53NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL26623650 | 0.85 | MAPT (0.43) | NPC1RAB9AMAPTGSK3BSIRT3 | |
| SCHEMBL30600744 | 0.82 | KDM4C (0.50) | MAPTGSK3BSIRT3TDP1MEN1 | |
| SCHEMBL2033252 | 0.82 | KDM4C (0.50) | MAPTGSK3BSIRT3TDP1MEN1 | |
| SCHEMBL14818762 | 0.82 | POLB (0.54) | RAB9ASMN1; SMN2HTTMEN1LMNA | |
| SCHEMBL6634771 | 0.81 | MAPT (0.46) | MDM4TP53MAPTGSK3BCETP | |
| SCHEMBL6635011 | 0.81 | MAPT (0.51) | MDM4TP53NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30418934 | 0.80 | ALDH1A1 (0.55) | MAPTGSK3BSIRT3TDP1MEN1 | |
| SCHEMBL1637363 | 0.80 | ALDH1A1 (0.55) | MAPTGSK3BSIRT3TDP1MEN1 | |
| SCHEMBL16303156 | 0.79 | GAA (0.51) | MDM4TP53MAPTGSK3BCETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022169974-A1 | INHIBITORS OF URAT1 AND PHARMACEUTICAL USES THEREOF | NEXYS THERAPEUTICS, INC. (US) | 2022-08-11 | — | — | WO | disclosed |