Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31690840 | 1.00 | CYP1A2 (0.44) | CYP1A2GRM5PTPN11NOS3NOS1 | |
| SCHEMBL31690851 | 0.93 | GRM5 (0.53) | CYP1A2GRM5PTPN11NOS3NOS1 | |
| SCHEMBL2592722 | 0.92 | CYP1A2 (0.39) | CYP1A2GRM5PTPN11NOS3NOS1 | |
| SCHEMBL14740065 | 0.92 | CYP1A2 (0.39) | CYP1A2GRM5PTPN11NOS3NOS1 | |
| SCHEMBL31690836 | 0.92 | GRM5 (0.55) | CYP1A2GRM5PTPN11NOS3NOS1 | |
| SCHEMBL30942701 | 0.89 | CYP1A2 (0.39) | CYP1A2GRM5PTPN11NOS3NOS1 | |
| SCHEMBL23858285 | 0.82 | PIK3CD (0.38) | CYP1A2GRM5NAPRTPIK3CDPIK3CA | |
| SCHEMBL15730262 | 0.79 | CYP1A2 (0.47) | CYP1A2GRM5PTPN11KCNH2PGK1 | |
| SCHEMBL18188415 | 0.79 | GRM5 (0.44) | CYP1A2GRM5PTPN11PDK2KCNH2 | |
| SCHEMBL15723883 | 0.76 | CYP1A2 (0.41) | CYP1A2GRM5PTPN11PIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022169974-A1 | INHIBITORS OF URAT1 AND PHARMACEUTICAL USES THEREOF | NEXYS THERAPEUTICS, INC. (US) | 2022-08-11 | — | — | WO | disclosed |