Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14740065 | 1.00 | CYP1A2 (0.39) | CYP1A2GRM5PTPN11NOS3NOS1 | |
| SCHEMBL29856498 | 0.92 | CYP1A2 (0.44) | CYP1A2GRM5PTPN11NOS3NOS1 | |
| SCHEMBL31690840 | 0.92 | CYP1A2 (0.44) | CYP1A2GRM5PTPN11NOS3NOS1 | |
| SCHEMBL31690851 | 0.86 | GRM5 (0.53) | CYP1A2GRM5PTPN11NOS3NOS1 | |
| SCHEMBL31690836 | 0.84 | GRM5 (0.55) | CYP1A2GRM5PTPN11NOS3NOS1 | |
| SCHEMBL30942701 | 0.82 | CYP1A2 (0.39) | CYP1A2GRM5PTPN11NOS3NOS1 | |
| SCHEMBL23858285 | 0.78 | PIK3CD (0.38) | CYP1A2GRM5NAPRTPIK3CDPIK3CA | |
| SCHEMBL13268444 | 0.73 | KDM4E (0.39) | CYP1A2GRM5PTPN11PIK3CDPIK3CA | |
| SCHEMBL18188415 | 0.72 | GRM5 (0.44) | CYP1A2GRM5PTPN11 | |
| SCHEMBL15730262 | 0.72 | CYP1A2 (0.47) | CYP1A2GRM5PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566481-A1 | AZA-INDOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | Merck Sharp & Dohme Corp. (US) | 2013-03-13 | — | — | EP | disclosed |
| US-20130059850-A1 | AZA-INDOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | MERCK SHARP & DOHME CORP. (US) | 2013-03-07 | — | — | US | disclosed |
| WO-2011140164-A1 | AZA-INDOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | MERCK SHARP & DOHME CORP. (US) | 2011-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130059850-A1 | AZA-INDOLE DERIVATIVES USEFUL AS MODULATORS OF FAAH | FAAH, FAAH2, IDO1 | CYP1A2 598/4885GRM5 328/4885PTPN11 3300/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.