Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 20/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 1.00 |
| ▸ | HTR1A | P08908 | 2/20 | 0.77 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.77 |
| ▸ | HTR2A | P28223 | 2/20 | 0.77 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.77 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.77 |
| ▸ | HTR2B | P41595 | 2/20 | 0.77 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2931195 | 1.00 | REN (1.00) | RENCYP3A4HTR1AADRA1DHTR2A | |
| SCHEMBL2936894 | 1.00 | REN (1.00) | RENCYP3A4HTR1AADRA1DHTR2A | |
| SCHEMBL2932453 | 0.93 | REN (0.87) | RENCYP3A4 | |
| SCHEMBL2936487 | 0.93 | REN (0.86) | RENCYP3A4HTR1AADRA1DHTR2A | |
| SCHEMBL2935947 | 0.93 | REN (0.86) | RENCYP3A4HTR1AADRA1DHTR2A | |
| SCHEMBL2936120 | 0.93 | REN (0.86) | RENCYP3A4 | |
| SCHEMBL2938433 | 0.93 | REN (0.86) | RENCYP3A4 | |
| SCHEMBL2937865 | 0.93 | REN (1.00) | RENCYP3A4HTR1AADRA1DHTR2A | |
| SCHEMBL2936386 | 0.92 | REN (0.85) | RENCYP3A4HTR1AADRA1DHTR2A | |
| SCHEMBL2931598 | 0.92 | REN (0.85) | RENCYP3A4HTR1AADRA1DHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836163-B1 | PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN | NOVARTIS AG (CH) | 2010-09-22 | — | — | EP | disclosed |
| US-20100087427-A1 | PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN | BREITENSTEIN WERNER | 2010-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087427-A1 | PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN | REN, ACE, PEPD | REN 1/4885CYP3A4 959/4885HTR1A 2770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.