Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 1/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | PLG | P00747 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | KLK1 | P06870 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | ILK | Q13418 | 2/20 | 0.34 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.34 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 9/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29859798 | 0.81 | IKBKE (0.48) | IKBKETBK1ILKTGFBR1LRRK2 | |
| SCHEMBL27029460 | 0.71 | TBK1 (0.45) | IKBKETBK1ILKTGFBR1LRRK2 | |
| SCHEMBL30492158 | 0.62 | F2 (0.40) | F2PLGPLAUKLK1PRSS1 | |
| SCHEMBL16598078 | 0.60 | CCNC (0.38) | IKBKETBK1PLAULRRK2 | |
| SCHEMBL30388731 | 0.60 | MAPK1 (0.41) | IKBKETBK1LRRK2 | |
| SCHEMBL4208416 | 0.59 | PIK3CG (0.59) | — | |
| SCHEMBL24576965 | 0.58 | CHEK1 (0.37) | JAK2JAK3 | |
| SCHEMBL30761152 | 0.57 | CCNC (0.43) | IKBKETBK1PLAULRRK2 | |
| SCHEMBL13735539 | 0.57 | LRRK2 (0.39) | IKBKETBK1LRRK2 | |
| Hydrochloric Acid SCHEMBL29759885 | 0.57 | CHEK1 (0.37) | JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308115-A1 | HETEROAROYL AMIDES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | Merck Sharp & Dohme LLC (US) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022197577-A1 | HETEROAROYL AMIDES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | MERCK SHARP & DOHME LLC (US) | 2022-09-22 | — | — | WO | disclosed |