Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | SYK | P43405 | 5/20 | 0.47 |
| ▸ | IGF1R | P08069 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.44 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27047622 | 1.00 | MEN1 (0.56) | MEN1KMT2ASYKIGF1REGFR | |
| SCHEMBL14368042 | 0.85 | RAPGEF4 (0.50) | SYKEGFRGRM4CDK5CDK5R1 | |
| SCHEMBL9945496 | 0.82 | EGFR (0.61) | MEN1KMT2ASYKIGF1REGFR | |
| SCHEMBL1024631 | 0.82 | BTK (0.44) | MEN1KMT2ASYKIGF1REGFR | |
| SCHEMBL2386416 | 0.82 | SYK (0.70) | SYK | |
| SCHEMBL4175837 | 0.81 | SYK (0.51) | MEN1KMT2ASYKIGF1REGFR | |
| SCHEMBL655633 | 0.80 | SYK (0.72) | MEN1KMT2ASYKIGF1REGFR | |
| SCHEMBL1774193 | 0.78 | IGF1R (0.68) | MEN1KMT2ASYKIGF1REGFR | |
| SCHEMBL15994648 | 0.78 | BTK (0.49) | MEN1KMT2ASYKIGF1REGFR | |
| SCHEMBL13622715 | 0.77 | SYK (0.48) | MEN1KMT2ASYKIGF1REGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115348963-B | Pyridopyrimidine compound and application thereof | 暨南大学 | 2024-04-19 | — | — | CN | disclosed |
| EP-4310084-A1 | PYRIDOPYRIMIDINE-BASED COMPOUND AND APPLICATION THEREOF | Jinan University (CN) | 2024-01-24 | — | — | EP | disclosed |
| CN-115348963-A | Pyridopyrimidine compound and application thereof | 暨南大学 | 2022-11-15 | — | — | CN | disclosed |
| WO-2022188755-A1 | PYRIDOPYRIMIDINE-BASED COMPOUND AND APPLICATION THEREOF | 暨南大学 | 2022-09-15 | — | — | WO | disclosed |