Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 7/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 10/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10249765 | 0.88 | CYP3A4 (0.49) | CYP2C19CYP2C9CYP3A4 | |
| SCHEMBL77863 | 0.87 | CYP2C19 (0.67) | CYP2C19CYP2C9CYP3A4 | |
| SCHEMBL298260 | 0.85 | CYP3A4 (0.62) | CYP2C19CYP2C9CYP3A4 | |
| SCHEMBL288130 | 0.83 | SLC40A1 (0.53) | CYP2C19CYP2C9CYP3A4 | |
| SCHEMBL287955 | 0.80 | CYP2C9 (0.66) | CYP2C19CYP2C9CYP3A4 | |
| SCHEMBL77073 | 0.79 | CYP3A4 (0.75) | CYP2C19CYP2C9CYP3A4 | |
| SCHEMBL287506 | 0.77 | CYP2C9 (0.59) | CYP2C19CYP2C9CYP3A4 | |
| SCHEMBL76827 | 0.77 | CYP2C9 (0.48) | CYP2C19CYP2C9CYP3A4 | |
| SCHEMBL298358 | 0.76 | CYP2C9 (0.62) | CYP2C19CYP2C9CYP3A4 | |
| SCHEMBL298151 | 0.76 | CYP2C9 (0.62) | CYP2C19CYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120122860-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | PLEXXIKON, INC. | 2012-05-17 | — | — | US | disclosed |
| EP-2427433-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | Plexxikon, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010129570-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | PLEXXIKON, INC. (US) | 2010-11-11 | — | — | WO | disclosed |
| WO-2010129570-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | PLEXXIKON, INC. (US) | 2010-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122860-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | BRAF, RAF1, ARAF | CYP2C19 2730/4885CYP2C9 2176/4885CYP3A4 3611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.