SCHEMBL29862091

SCHEMBL29862091

CC(C)COc1cc(F)cc(-c2ccc(C(=O)OC(C)(C)C)c(Cl)n2)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AAK1 Q2M2I8 13/20 0.41
FFAR4 Q5NUL3 1/20 0.41
LDHA P00338 3/20 0.39
CTSA P10619 1/20 0.39
CIT O14578 1/20 0.35
DAPK3 O43293 1/20 0.35
JAK2 O60674 1/20 0.35
DAPK1 P53355 1/20 0.35
MAP2K1 Q02750 1/20 0.35
PKN2 Q16513 1/20 0.35
TLK2 Q86UE8 1/20 0.35
HIPK4 Q8NE63 1/20 0.35
MKNK1 Q9BUB5 1/20 0.35
MYLK2 Q9H1R3 1/20 0.35
MKNK2 Q9HBH9 1/20 0.35
BMP2K Q9NSY1 1/20 0.35
STK39 Q9UEW8 1/20 0.35
TLK1 Q9UKI8 1/20 0.35
SCN9A Q15858 2/20 0.34
FPR2 P25090 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17647428 1.00 AAK1 (0.41) AAK1FFAR4LDHACTSACIT
SCHEMBL19440642 0.89 NPC1 (0.43) AAK1FFAR4LDHACTSACIT
SCHEMBL17648799 0.87 FFAR4 (0.41) FFAR4LDHACTSAJAK2
SCHEMBL17646752 0.86 LDHA (0.47) FFAR4LDHACTSA
SCHEMBL29862268 0.86 LDHA (0.47) FFAR4LDHACTSA
SCHEMBL28490188 0.85 FFAR4 (0.43) AAK1FFAR4LDHACTSACIT
SCHEMBL13053992 0.85 NPC1 (0.39) AAK1LDHASCN9AFPR2
SCHEMBL19412304 0.78 FFAR4 (0.47) FFAR4LDHACTSA
SCHEMBL20633285 0.78 FFAR4 (0.41) FFAR4LDHACTSASCN9A
SCHEMBL17648004 0.77 EGFR (0.50) FFAR4CTSASCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3436446-B1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMA (US) 2023-06-07 EP disclosed
EP-4013759-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR Vertex Pharmaceuticals Incorporated (US) 2022-06-22 EP disclosed