Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 2/20 | 0.42 |
| ▸ | PRKCI | P41743 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 4/20 | 0.38 |
| ▸ | JAK1 | P23458 | 4/20 | 0.38 |
| ▸ | TYK2 | P29597 | 3/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
| ▸ | CCNK | O75909 | 1/20 | 0.36 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.36 |
| ▸ | RHEB | Q15382 | 1/20 | 0.36 |
| ▸ | CIT | O14578 | 5/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 2/20 | 0.34 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27282728 | 1.00 | NUDT1 (0.42) | NUDT1PRKCIJAK2JAK1TYK2 | |
| SCHEMBL29862246 | 0.93 | RHEB (0.38) | NUDT1PRKCIJAK2JAK1TYK2 | |
| SCHEMBL27282657 | 0.93 | RHEB (0.38) | NUDT1PRKCIJAK2JAK1TYK2 | |
| SCHEMBL27282737 | 0.92 | NUDT1 (0.43) | NUDT1PRKCIJAK2JAK1TYK2 | |
| SCHEMBL27282734 | 0.92 | NUDT1 (0.43) | NUDT1PRKCIJAK2JAK1TYK2 | |
| SCHEMBL27282755 | 0.92 | NUDT1 (0.43) | NUDT1PRKCIJAK2JAK1TYK2 | |
| SCHEMBL27282753 | 0.91 | NUDT1 (0.42) | NUDT1PRKCIJAK2JAK1TYK2 | |
| SCHEMBL27282749 | 0.91 | NUDT1 (0.42) | NUDT1PRKCIJAK2JAK1TYK2 | |
| SCHEMBL29862299 | 0.90 | NUDT1 (0.42) | NUDT1PRKCIJAK2JAK1TYK2 | |
| SCHEMBL27282773 | 0.90 | NUDT1 (0.42) | NUDT1PRKCIJAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313971-A1 | SUBSTITUTED PYRROLE CARBOXAMIDES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2024-02-07 | — | — | EP | disclosed |
| CN-117157289-A | Substituted pyrrolecarboxamides, process for their preparation and their use as kinase inhibitors | 内尔维亚诺医疗科学公司 | 2023-12-01 | — | — | CN | disclosed |
| WO-2022207404-A1 | SUBSTITUTED PYRROLE CARBOXAMIDES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2022-10-06 | — | — | WO | disclosed |