Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | TTK | P33981 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 4/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.34 |
| ▸ | G6PD | P11413 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22412980 | 1.00 | MAPT (0.42) | MAPTCASP1AURKATTKAURKB | |
| SCHEMBL12113644 | 0.79 | ALDH1A1 (0.35) | MAPTNPC1TSHRSMN1; SMN2 | |
| SCHEMBL17681856 | 0.77 | MAPT (0.37) | MAPTCASP1AURKATTKAURKB | |
| SCHEMBL29687317 | 0.77 | MAPT (0.37) | MAPTCASP1AURKATTKAURKB | |
| SCHEMBL22224634 | 0.75 | HTT (0.37) | MAPTCASP1AURKATTKAURKB | |
| SCHEMBL22207396 | 0.74 | PIK3CA (0.36) | MAPTCASP1AURKATTKAURKB | |
| SCHEMBL22412994 | 0.74 | PDCD1 (0.32) | MAPTCASP1AURKATTKAURKB | |
| SCHEMBL7366030 | 0.72 | ALDH1A1 (0.43) | MAPTCASP1AURKATTKAURKB | |
| SCHEMBL21598414 | 0.72 | AURKA (0.43) | MAPTCASP1AURKATTKAURKB | |
| SCHEMBL1959885 | 0.72 | MAPT (0.53) | MAPTCASP1AURKATTKAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114901279-A | Inhibitors of cGAS for the treatment of autoinflammatory diseases and cancer metastasis | 洛克菲勒大学 | 2022-08-12 | — | — | CN | disclosed |