Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.40 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.40 |
| ▸ | CRACR2A | Q9BSW2 | 8/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14887733 | 1.00 | KDM4E (0.42) | KDM4EALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL14996569 | 0.85 | KDM4E (0.44) | KDM4EALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL14881344 | 0.82 | ALDH1A1 (0.42) | KDM4EALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL25292186 | 0.82 | KDM4E (0.42) | KDM4EALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL29864237 | 0.82 | ALDH1A1 (0.42) | KDM4EALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL13105375 | 0.80 | MAPT (0.51) | KDM4EALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL29864100 | 0.80 | MAPT (0.45) | KDM4EALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL25292190 | 0.79 | STIM1 (0.41) | KDM4EALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL25247038 | 0.79 | STIM1 (0.41) | KDM4EALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL31504037 | 0.79 | STIM1 (0.41) | KDM4EALDH1A1HPGDTSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4291559-A1 | PYRROLO[3,2-D]PYRIMIDINE COMPOUNDS AND METHODS OF USE IN THE TREATMENT OF CANCER | Tango Therapeutics, Inc. (US) | 2023-12-20 | — | — | EP | disclosed |
| WO-2022174184-A1 | PYRROLO[3,2-D]PYRIMIDINE COMPOUNDS AND METHODS OF USE IN THE TREATMENT OF CANCER | TANGO THERAPEUTICS, INC. (US) | 2022-08-18 | — | — | WO | disclosed |