Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.53 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.53 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.53 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27988267 | 0.85 | TNIK (0.53) | TNIKMAP4K4PDGFRBPDGFRASMN1; SMN2 | |
| SCHEMBL29870004 | 0.77 | FGFR2 (0.53) | MAP4K4MKNK2CSNK1G2CLK4MAP4K5 | |
| SCHEMBL24117372 | 0.75 | CYP2A6 (0.56) | MAP4K4MKNK2CSNK1G2CLK4MAP4K5 | |
| SCHEMBL8889438 | 0.75 | PDGFRB (0.55) | TNIKMAP4K4MKNK2CSNK1G2CLK4 | |
| SCHEMBL31565774 | 0.75 | TNIK (0.71) | TNIKMAP4K4MKNK2CSNK1G2CLK4 | |
| SCHEMBL18995965 | 0.75 | KDM4E (0.57) | KDM4EMEN1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL29869661 | 0.74 | MAP4K4 (0.46) | MAP4K4MKNK2CSNK1G2CLK4MAP4K5 | |
| SCHEMBL15447361 | 0.74 | MAP4K4 (0.46) | MAP4K4MKNK2CSNK1G2CLK4MAP4K5 | |
| SCHEMBL4448294 | 0.74 | SMN1; SMN2 (0.64) | KDM4EMEN1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL30523316 | 0.74 | MAPT (0.48) | MAP4K4MKNK2CSNK1G2CLK4MAP4K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107312009-B | Quinoline compound, preparation method, intermediate, pharmaceutical composition and application thereof | 上海医药集团股份有限公司 | 2022-09-20 | — | — | CN | disclosed |