Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 2/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.50 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.50 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.48 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.48 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.47 |
| ▸ | RXRA | P19793 | 1/20 | 0.47 |
| ▸ | RXRB | P28702 | 1/20 | 0.47 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.46 |
| ▸ | BAD | Q92934 | 1/20 | 0.46 |
| ▸ | HPGDS | O60760 | 1/20 | 0.46 |
| ▸ | KMO | O15229 | 1/20 | 0.46 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 2/20 | 0.45 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8499693 | 0.93 | PDGFRB (0.52) | PDGFRBPDGFRAMAP4K4CHEK2CSNK1G2 | |
| Hydrochloric Acid SCHEMBL8891443 | 0.90 | PDGFRB (0.53) | PDGFRBPDGFRAMAP4K4CHEK2CSNK1G2 | |
| SCHEMBL8502256 | 0.85 | CSNK2A2 (0.54) | PDGFRBPDGFRAMAP4K4CHEK2CSNK1G2 | |
| SCHEMBL30189289 | 0.84 | BCL2L1 (0.64) | RXRARXRBBCL2L1BADKMO | |
| SCHEMBL505269 | 0.84 | BCL2L1 (0.64) | RXRARXRBBCL2L1BADKMO | |
| SCHEMBL4123055 | 0.83 | MGAM (0.58) | PDGFRBPDGFRAMAP4K4CSNK1G2CLK4 | |
| SCHEMBL8503239 | 0.82 | DHODH (0.49) | PDGFRBPDGFRAMAP4K4CHEK2CSNK1G2 | |
| SCHEMBL8502253 | 0.82 | PDGFRB (0.64) | PDGFRBPDGFRAMAP4K4CSNK1G2CLK4 | |
| SCHEMBL8887276 | 0.81 | CHEK2 (0.53) | MAP4K4CHEK2CSNK2A2CSNK2BHPGDS | |
| SCHEMBL8503378 | 0.81 | PDGFRB (0.57) | PDGFRBPDGFRAMAP4K4CHEK2CSNK1G2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5646153-A | INHIBITING ABNORMAL CELL PROLIFERATION | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1997-07-08 | — | — | US | disclosed |
| US-5480883-A | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-01-02 | — | — | US | disclosed |