⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31612008 | 0.80 | TSHR (0.36) | — | |
| SCHEMBL15691410 | 0.78 | TSHR (0.34) | — | |
| SCHEMBL16572130 | 0.78 | TSHR (0.34) | — | |
| SCHEMBL27502465 | 0.76 | — | — | |
| SCHEMBL29096981 | 0.76 | — | — | |
| Hydrochloric Acid SCHEMBL27567865 | 0.75 | GRM6 (0.37) | — | |
| SCHEMBL5988699 | 0.72 | TSHR (0.30) | — | |
| SCHEMBL5987300 | 0.72 | MAPK8 (0.30) | — | |
| SCHEMBL17614995 | 0.72 | TSHR (0.30) | — | |
| SCHEMBL15417508 | 0.70 | GPR35 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4725493-A2 | POLYCYCLIC COMPOUNDS FOR INHIBITING RNA HELICASE DHX33 AND USE THEREOF | Shenzhen Keye Life Technologies, Co., Ltd. (CN) | 2026-04-15 | — | — | EP | disclosed |
| US-20250295652-A1 | Inhibitors of Molluscum Contagiosum Infection and Methods Using the Same | UNIV PENNSYLVANIA (US) | 2025-09-25 | — | — | US | disclosed |
| CN-112538078-B | Polycyclic compound for inhibiting DHX33 helicase | 成都开悦生命科技有限公司 | 2024-03-19 | — | — | CN | disclosed |
| CN-112661754-B | Polycyclic compound for inhibiting RNA helicase DHX33 | 成都开悦生命科技有限公司 | 2023-06-16 | — | — | CN | disclosed |
| US-20230146233-A1 | A CLASS OF POLYCYCLIC COMPOUNDS INHIBITING RNA HELICASE DHX33 AND THE APPLICATION THEREOF | SHENZHEN KEYE LIFE TECHNOLOGIES, CO., LTD (CN) | 2023-05-11 | — | — | US | disclosed |
| EP-4089089-A1 | POLYCYCLIC COMPOUNDS FOR INHIBITING RNA HELICASE DHX33 AND USE THEREOF | Shenzhen Keye Life Technologies, Co., Ltd. (CN) | 2022-11-16 | — | — | EP | disclosed |
| WO-2022127199-A1 | POLYCYCLIC COMPOUNDS FOR INHIBITING RNA HELICASE DHX33 AND USE THEREOF | 深圳开悦生命科技有限公司 | 2022-06-23 | — | — | WO | disclosed |