Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 12/20 | 0.52 |
| ▸ | ESRRA | P11474 | 7/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.51 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | ESRRB | O95718 | 6/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23388572 | 1.00 | ESR1 (0.52) | ESR1ESRRAESR2CYP3A4CYP2C19 | |
| SCHEMBL23388574 | 1.00 | ESR1 (0.52) | ESR1ESRRAESR2CYP3A4CYP2C19 | |
| SCHEMBL23388683 | 0.98 | ESR1 (0.54) | ESR1ESRRAESR2CYP3A4CYP2C19 | |
| SCHEMBL30489186 | 0.98 | ESR1 (0.54) | ESR1ESRRAESR2CYP3A4CYP2C19 | |
| SCHEMBL29871878 | 0.98 | ESR1 (0.54) | ESR1ESRRAESR2CYP3A4CYP2C19 | |
| SCHEMBL26097958 | 0.98 | ESR1 (0.54) | ESR1ESRRAESR2CYP3A4CYP2C19 | |
| SCHEMBL23388584 | 0.95 | ESR1 (0.55) | ESR1ESRRAESR2CYP3A4CYP2C19 | |
| SCHEMBL26100714 | 0.95 | ESR1 (0.55) | ESR1ESRRAESR2CYP3A4CYP2C19 | |
| SCHEMBL29871506 | 0.95 | ESR1 (0.55) | ESR1ESRRAESR2CYP3A4CYP2C19 | |
| SCHEMBL30489035 | 0.94 | ESR1 (0.55) | ESR1ESRRAESR2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4061376-A2 | PRODRUGS OF FULVESTRANT | Kashiv Biosciences, LLC (US) | 2022-09-28 | — | — | EP | disclosed |