Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS7 | Q9UKP4 | 12/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | ADAMTS5 | Q9UNA0 | 5/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.42 |
| ▸ | MMP2 | P08253 | 4/20 | 0.42 |
| ▸ | MMP13 | P45452 | 4/20 | 0.42 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | ADAMTS1 | Q9UHI8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29873733 | 1.00 | ADAMTS7 (0.62) | ADAMTS7HDAC1ADAMTS5ADAM17MMP2 | |
| SCHEMBL23354934 | 1.00 | ADAMTS7 (0.62) | ADAMTS7HDAC1ADAMTS5ADAM17MMP2 | |
| SCHEMBL29873462 | 0.93 | ADAMTS7 (0.61) | ADAMTS7ADAMTS5ADAM17MMP2MMP13 | |
| SCHEMBL23354827 | 0.93 | ADAMTS7 (0.61) | ADAMTS7ADAMTS5ADAM17MMP2MMP13 | |
| SCHEMBL29874171 | 0.93 | ADAMTS7 (0.61) | ADAMTS7ADAMTS5ADAM17MMP2MMP13 | |
| SCHEMBL23354726 | 0.85 | ADAMTS7 (0.63) | ADAMTS7HDAC1ADAMTS5ADAM17MMP2 | |
| SCHEMBL29873601 | 0.85 | ADAMTS7 (0.63) | ADAMTS7HDAC1ADAMTS5ADAM17MMP2 | |
| SCHEMBL23354786 | 0.85 | ADAMTS7 (0.58) | ADAMTS7HDAC1ADAMTS5ADAM17MMP2 | |
| SCHEMBL29873949 | 0.85 | ADAMTS7 (0.58) | ADAMTS7HDAC1ADAMTS5ADAM17MMP2 | |
| SCHEMBL23354752 | 0.81 | ADAMTS7 (0.65) | ADAMTS7HDAC1ADAMTS5ADAM17MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4058446-A1 | SUBSTITUTED HYDANTOINAMIDES AS ADAMTS7 ANTAGONISTS | Bayer Aktiengesellschaft (DE) | 2022-09-21 | — | — | EP | disclosed |