Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK4 | Q16654 | 1/20 | 0.60 |
| ▸ | DDB1 | Q16531 | 18/20 | 0.56 |
| ▸ | CRBN | Q96SW2 | 18/20 | 0.56 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.52 |
| ▸ | TNF | P01375 | 1/20 | 0.52 |
| ▸ | IL1B | P01584 | 1/20 | 0.52 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.52 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23250139 | 1.00 | PDK4 (0.60) | PDK4DDB1CRBNIKZF3TNF | |
| SCHEMBL30047819 | 0.90 | PDK4 (0.50) | PDK4DDB1CRBNIKZF3TNF | |
| SCHEMBL27157400 | 0.90 | PDK4 (0.50) | PDK4DDB1CRBNIKZF3TNF | |
| SCHEMBL24329646 | 0.85 | PDK4 (0.51) | PDK4DDB1CRBNIKZF3ALDH1A1 | |
| SCHEMBL29367280 | 0.85 | CRBN (0.54) | PDK4DDB1CRBNIKZF3ALDH1A1 | |
| SCHEMBL20046320 | 0.85 | CRBN (0.54) | PDK4DDB1CRBNIKZF3ALDH1A1 | |
| SCHEMBL21996905 | 0.84 | CRBN (0.63) | DDB1CRBN | |
| SCHEMBL26621089 | 0.84 | PDK4 (0.49) | PDK4DDB1CRBNIKZF3ALDH1A1 | |
| SCHEMBL31323443 | 0.84 | PDK4 (0.53) | PDK4DDB1CRBNIKZF3ALDH1A1 | |
| SCHEMBL19585546 | 0.83 | CRBN (0.55) | PDK4DDB1CRBNIKZF3TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4452978-A1 | BIFUNCTIONAL ARYLSULPHONAMIDE COMPOUNDS | Anaxis Pharma Pty Ltd (AU) | 2024-10-30 | — | — | EP | disclosed |
| WO-2023115150-A1 | BIFUNCTIONAL ARYLSULPHONAMIDE COMPOUNDS | Anaxis Pharma Pty Ltd (AU) | 2023-06-29 | — | — | WO | disclosed |
| EP-4146660-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | Nurix Therapeutics, Inc. (US) | 2023-03-15 | — | — | EP | disclosed |
| EP-4045496-A1 | BIFUNCTIONAL MOLECULES CONTAINING AN E3 UBIQUITINE LIGASE BINDING MOIETY LINKED TO A BCL6 TARGETING MOIETY | Arvinas Operations, Inc. (US) | 2022-08-24 | — | — | EP | disclosed |