Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK4 | Q16654 | 1/20 | 0.50 |
| ▸ | CRBN | Q96SW2 | 16/20 | 0.49 |
| ▸ | DDB1 | Q16531 | 15/20 | 0.49 |
| ▸ | TNF | P01375 | 2/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | IL1B | P01584 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.44 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 2/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27157400 | 1.00 | PDK4 (0.50) | PDK4CRBNDDB1TNFJAK1 | |
| SCHEMBL29874068 | 0.90 | PDK4 (0.60) | PDK4CRBNDDB1TNFIL1B | |
| SCHEMBL23250139 | 0.90 | PDK4 (0.60) | PDK4CRBNDDB1TNFIL1B | |
| SCHEMBL20046320 | 0.86 | CRBN (0.54) | PDK4CRBNDDB1JAK1IKZF3 | |
| SCHEMBL29367280 | 0.86 | CRBN (0.54) | PDK4CRBNDDB1JAK1IKZF3 | |
| SCHEMBL25133945 | 0.85 | IKZF1 (0.52) | PDK4CRBNDDB1TNFJAK1 | |
| SCHEMBL29583349 | 0.85 | IKZF1 (0.52) | PDK4CRBNDDB1TNFJAK1 | |
| SCHEMBL20046894 | 0.84 | CRBN (0.51) | CRBNDDB1TNFIL1BTBXA2R | |
| SCHEMBL30047364 | 0.82 | CRBN (0.49) | CRBNDDB1TNFIL1BTBXA2R | |
| SCHEMBL27157350 | 0.82 | CRBN (0.49) | CRBNDDB1TNFIL1BTBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4329744-A1 | SUBSTITUTED 2-(2,6-DIOXOPIPERIDIN-3-YL)-5-(1-PIPERIDIN-4-YL)ISOINDOLINE-1,3-DIONE DERIVATIVES AND USES THEREOF | Neomorph, Inc. (US) | 2024-03-06 | — | — | EP | disclosed |
| WO-2022232536-A1 | SUBSTITUTED 2-(2,6-DIOXOPIPERIDIN-3-YL)-5-(1-PIPERIDIN-4-YL)ISOINDOLINE-1,3-DIONE DERIVATIVES AND USES THEREOF | NEOMORPH, INC. (US) | 2022-11-03 | — | — | WO | disclosed |