Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 19/20 | 0.50 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.49 |
| ▸ | IKZF2 | Q9UKS7 | 1/20 | 0.49 |
| ▸ | IKZF3 | Q9UKT9 | 18/20 | 0.48 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | TNF | P01375 | 1/20 | 0.47 |
| ▸ | IL1B | P01584 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23250121 | 1.00 | CRBN (0.50) | CRBNIKZF1IKZF2IKZF3DDB1 | |
| SCHEMBL31129437 | 0.95 | IKZF1 (0.49) | CRBNIKZF1IKZF2IKZF3DDB1 | |
| SCHEMBL31129754 | 0.91 | CRBN (0.52) | CRBNIKZF1IKZF3DDB1BRD4 | |
| SCHEMBL30135733 | 0.91 | CRBN (0.58) | CRBNIKZF1IKZF3DDB1BRD4 | |
| SCHEMBL27099085 | 0.91 | CRBN (0.58) | CRBNIKZF1IKZF3DDB1BRD4 | |
| SCHEMBL31747465 | 0.89 | CRBN (0.55) | CRBNIKZF1IKZF3DDB1BRD4 | |
| SCHEMBL31129758 | 0.88 | IKZF2 (0.56) | CRBNIKZF1IKZF2IKZF3DDB1 | |
| SCHEMBL31129642 | 0.88 | IKZF2 (0.48) | CRBNIKZF1IKZF2IKZF3DDB1 | |
| SCHEMBL31752706 | 0.87 | CRBN (0.53) | CRBNIKZF1IKZF3DDB1BRD4 | |
| SCHEMBL25133788 | 0.87 | CRBN (0.48) | CRBNIKZF1IKZF2IKZF3DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4045496-A1 | BIFUNCTIONAL MOLECULES CONTAINING AN E3 UBIQUITINE LIGASE BINDING MOIETY LINKED TO A BCL6 TARGETING MOIETY | Arvinas Operations, Inc. (US) | 2022-08-24 | — | — | EP | disclosed |