⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24641068 | 1.00 | — | — | |
| SCHEMBL17926752 | 0.75 | — | — | |
| SCHEMBL518554 | 0.73 | — | — | |
| SCHEMBL1459930 | 0.73 | — | — | |
| Hydrochloric Acid SCHEMBL28507568 | 0.71 | FAAH (0.43) | — | |
| Hydrochloric Acid SCHEMBL6207350 | 0.71 | — | — | |
| SCHEMBL5610307 | 0.70 | FAAH (0.42) | — | |
| SCHEMBL1231949 | 0.67 | FAAH (0.47) | — | |
| SCHEMBL28892029 | 0.67 | FAAH (0.39) | — | |
| SCHEMBL11130354 | 0.67 | FAAH (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117479934-A | HIPK2 inhibitors for the treatment of renal fibrosis | 西奈山伊坎医学院 | 2024-01-30 | — | — | CN | disclosed |
| EP-4291183-A1 | OXADIAZOLYL DIHYDROPYRANO[2,3-B]PYRIDINE INHIBITORS OF HIPK2 FOR TREATING KIDNEY FIBROSIS | Icahn School of Medicine at Mount Sinai (US) | 2023-12-20 | — | — | EP | disclosed |
| WO-2022173795-A1 | OXADIAZOLYL DIHYDROPYRANO[2,3-b]PYRIDINE INHIBITORS OF HIPK2 FOR TREATING KIDNEY FIBROSIS | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2022-08-18 | — | — | WO | disclosed |