Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.32 |
| ▸ | RRM1 | P23921 | 2/20 | 0.32 |
| ▸ | RRM2B | Q7LG56 | 2/20 | 0.32 |
| ▸ | PLK4 | O00444 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | PRKCG | P05129 | 1/20 | 0.31 |
| ▸ | INSR | P06213 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | FES | P07332 | 1/20 | 0.31 |
| ▸ | IGF1R | P08069 | 1/20 | 0.31 |
| ▸ | ROS1 | P08922 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.31 |
| ▸ | FER | P16591 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL415659 | 0.91 | BRAF (0.34) | PDPK1CHRM2CHRM1RRM1RRM2B | |
| SCHEMBL298640 | 0.78 | BRAF (0.37) | PDPK1PLK4AURKAROCK2PRKD3 | |
| SCHEMBL413438 | 0.78 | BRAF (0.45) | CHRM2CHRM1PLK4AURKAMAP4K4 | |
| SCHEMBL287646 | 0.77 | RPS6KB1 (0.33) | PLK4AURKAMAP4K4FESFGFR1 | |
| SCHEMBL3715063 | 0.77 | AURKA (0.39) | PDPK1PLK4AURKAJAK2ROCK2 | |
| SCHEMBL2890696 | 0.74 | BRAF (0.43) | PDPK1CHRM2CHRM1RRM1RRM2B | |
| SCHEMBL299284 | 0.69 | BRAF (0.45) | CHRM2CHRM1PLK4AURKAMAP4K4 | |
| SCHEMBL995687 | 0.69 | BRAF (0.56) | CHRM2CHRM1PLK4AURKAMAP4K4 | |
| SCHEMBL3505142 | 0.69 | BRAF (0.39) | PDPK1PLK4AURKAJAK2ROCK2 | |
| SCHEMBL299060 | 0.69 | DYRK1A (0.42) | PDPK1DYRK1AMKNK2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427433-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | Plexxikon, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |