SCHEMBL29879043

SCHEMBL29879043

Nc1ccc(-c2cccc([Si](c3ccccc3)(c3ccccc3)c3ccccc3)c2)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 3/20 0.58
CYP3A4 P08684 3/20 0.58
TAAR1 Q96RJ0 2/20 0.58
TDP1 Q9NUW8 2/20 0.58
MAOA P21397 1/20 0.52
ALDH1A1 P00352 6/20 0.47
MEN1 O00255 5/20 0.47
KMT2A Q03164 5/20 0.47
MAPT P10636 4/20 0.47
HPGD P15428 4/20 0.47
KDM4E B2RXH2 4/20 0.47
RAB9A P51151 4/20 0.47
NPC1 O15118 3/20 0.47
GLA P06280 2/20 0.47
ALOX15 P16050 2/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
LMNA P02545 3/20 0.45
TP53 P04637 1/20 0.42
GAA P10253 2/20 0.41
USP2 O75604 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28874558 1.00 HSD17B10 (0.58) HSD17B10CYP3A4TAAR1TDP1MAOA
SCHEMBL13766205 0.90 MAOA (0.44) HSD17B10CYP3A4TAAR1TDP1MAOA
SCHEMBL13295273 0.88 MAOA (0.43) HSD17B10CYP3A4TAAR1MAOAALDH1A1
SCHEMBL13295278 0.88 MAOA (0.43) HSD17B10CYP3A4TAAR1MAOAALDH1A1
SCHEMBL25826093 0.88 MAOA (0.46) CYP3A4MAOAALDH1A1MEN1KMT2A
SCHEMBL20209438 0.86 MAOA (0.41) HSD17B10CYP3A4TAAR1MAOAALDH1A1
SCHEMBL17657680 0.86 CYP3A4 (0.64) HSD17B10CYP3A4TAAR1TDP1MAOA
Benzidine SCHEMBL9634896 0.86 CYP3A4 (0.64) HSD17B10CYP3A4TAAR1TDP1MAOA
SCHEMBL19051082 0.86 MAOA (0.44) CYP3A4MAOAALDH1A1MEN1KMT2A
SCHEMBL24604420 0.85 MAOA (0.42) MAOAALDH1A1MEN1KMT2AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115124516-A Light-emitting device and amine compound for light-emitting device 三星显示有限公司 2022-09-30 CN disclosed