Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 10/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.41 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24739954 | 1.00 | KLKB1 (0.42) | KLKB1DGAT1METTL3ALDH1A1HTT | |
| SCHEMBL29136951 | 1.00 | KLKB1 (0.42) | KLKB1DGAT1METTL3ALDH1A1HTT | |
| SCHEMBL29136948 | 1.00 | KLKB1 (0.42) | KLKB1DGAT1METTL3ALDH1A1HTT | |
| SCHEMBL29879552 | 0.92 | DGAT1 (0.42) | KLKB1DGAT1METTL3ALDH1A1HTT | |
| SCHEMBL24738588 | 0.92 | DGAT1 (0.42) | KLKB1DGAT1METTL3ALDH1A1HTT | |
| SCHEMBL29137013 | 0.92 | DGAT1 (0.42) | KLKB1DGAT1METTL3ALDH1A1HTT | |
| SCHEMBL29137014 | 0.92 | DGAT1 (0.42) | KLKB1DGAT1METTL3ALDH1A1HTT | |
| SCHEMBL24737849 | 0.90 | KLKB1 (0.41) | KLKB1DGAT1METTL3ALDH1A1HTT | |
| SCHEMBL29136869 | 0.90 | KLKB1 (0.41) | KLKB1DGAT1METTL3ALDH1A1HTT | |
| SCHEMBL29136871 | 0.90 | KLKB1 (0.41) | KLKB1DGAT1METTL3ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4585265-A2 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | Takeda Pharmaceutical Company Limited (JP) | 2025-07-16 | — | — | EP | disclosed |
| EP-4308230-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022197758-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |