Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 18/20 | 0.43 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24737872 | 1.00 | KLKB1 (0.43) | KLKB1METTL3KDM4ETP53 | |
| SCHEMBL24729466 | 0.81 | METTL3 (0.44) | KLKB1METTL3KDM4ETP53 | |
| SCHEMBL29879114 | 0.81 | METTL3 (0.44) | KLKB1METTL3KDM4ETP53 | |
| SCHEMBL30997805 | 0.80 | METTL3 (0.42) | KLKB1METTL3KDM4ETP53 | |
| SCHEMBL24739081 | 0.80 | METTL3 (0.42) | KLKB1METTL3KDM4ETP53 | |
| SCHEMBL29305098 | 0.78 | METTL3 (0.42) | KLKB1METTL3KDM4ETP53 | |
| SCHEMBL30997819 | 0.78 | METTL3 (0.42) | KLKB1METTL3KDM4ETP53 | |
| SCHEMBL30997765 | 0.78 | METTL3 (0.43) | KLKB1METTL3 | |
| SCHEMBL29958504 | 0.78 | KLKB1 (0.44) | KLKB1METTL3KDM4ETP53 | |
| SCHEMBL27033535 | 0.78 | KLKB1 (0.44) | KLKB1METTL3KDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308230-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022197758-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |