Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 2/20 | 0.31 |
| ▸ | MAP4K1 | Q92918 | 17/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29879631 | 1.00 | BTK (0.31) | BTKMAP4K1 | |
| SCHEMBL24740039 | 1.00 | BTK (0.31) | BTKMAP4K1 | |
| SCHEMBL29879864 | 0.89 | MAP4K1 (0.33) | MAP4K1 | |
| SCHEMBL24737796 | 0.89 | MAP4K1 (0.33) | MAP4K1 | |
| SCHEMBL29878844 | 0.85 | TYK2 (0.33) | MAP4K1 | |
| SCHEMBL24738376 | 0.85 | TYK2 (0.33) | MAP4K1 | |
| SCHEMBL24739200 | 0.84 | MAP4K1 (0.33) | MAP4K1 | |
| SCHEMBL29879676 | 0.84 | MAP4K1 (0.33) | MAP4K1 | |
| SCHEMBL29879492 | 0.84 | MAP4K1 (0.33) | MAP4K1 | |
| SCHEMBL29879310 | 0.84 | MAP4K1 (0.33) | MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308230-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022197758-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |