Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 17/20 | 0.40 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24737670 | 1.00 | DGAT1 (0.41) | DGAT1KLKB1METTL3LRRK2 | |
| SCHEMBL29136925 | 0.91 | KLKB1 (0.41) | DGAT1KLKB1METTL3 | |
| SCHEMBL29879204 | 0.91 | KLKB1 (0.41) | DGAT1KLKB1METTL3 | |
| SCHEMBL29136798 | 0.91 | KLKB1 (0.41) | DGAT1KLKB1METTL3 | |
| SCHEMBL24737981 | 0.91 | KLKB1 (0.41) | DGAT1KLKB1METTL3 | |
| SCHEMBL29879162 | 0.91 | KLKB1 (0.41) | DGAT1KLKB1METTL3 | |
| SCHEMBL29136795 | 0.91 | KLKB1 (0.41) | DGAT1KLKB1METTL3 | |
| SCHEMBL29879428 | 0.91 | KLKB1 (0.41) | DGAT1KLKB1METTL3 | |
| SCHEMBL29879418 | 0.91 | KLKB1 (0.41) | DGAT1KLKB1METTL3 | |
| SCHEMBL29880266 | 0.91 | KLKB1 (0.41) | DGAT1KLKB1METTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4585265-A2 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | Takeda Pharmaceutical Company Limited (JP) | 2025-07-16 | — | — | EP | disclosed |
| EP-4308230-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022197758-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |