Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | NPC1 | O15118 | 7/20 | 0.46 |
| ▸ | RAB9A | P51151 | 7/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23245919 | 1.00 | MAPT (0.49) | MAPTHPGDCYP1A2ALOX12CYP2C19 | |
| SCHEMBL28718664 | 0.85 | CYP1A2 (0.43) | MAPTHPGDCYP1A2POLBALDH1A1 | |
| SCHEMBL29883915 | 0.85 | CYP1A2 (0.43) | MAPTHPGDCYP1A2POLBALDH1A1 | |
| SCHEMBL23245940 | 0.84 | RAB9A (0.49) | MAPTHPGDCYP1A2ALOX12CYP2C19 | |
| SCHEMBL23245937 | 0.84 | RAB9A (0.49) | MAPTHPGDCYP1A2ALOX12CYP2C19 | |
| SCHEMBL22876522 | 0.84 | HTT (0.39) | MAPTHPGDCYP1A2ALOX12CYP2C19 | |
| SCHEMBL23245952 | 0.84 | CYP1A2 (0.49) | MAPTHPGDCYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL23245988 | 0.84 | RAB9A (0.49) | MAPTHPGDCYP1A2ALOX12CYP2C19 | |
| SCHEMBL29544498 | 0.81 | GAA (0.47) | MAPTHPGDPOLBALDH1A1GAA | |
| SCHEMBL3546699 | 0.78 | NPC1 (0.49) | MAPTHPGDPOLBALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4045506-A1 | DERIVATIVES OF 4-(IMIDAZO[1,2-A]PYRIDIN-3-YL)-N-(PYRIDIN-3-YL) PYRIMIDIN-2- AMINE FOR TREATING PROLIFERATIVE DISEASES AND CONDITIONS | Aucentra Therapeutics Pty Ltd (AU) | 2022-08-24 | — | — | EP | disclosed |