Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A3 | P47895 | 5/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.47 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.38 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL786129 | 1.00 | ALDH1A3 (0.49) | ALDH1A3HRH4ALDH1A1SMN1; SMN2TRIM24 | |
| SCHEMBL14232379 | 0.98 | HRH4 (0.50) | ALDH1A3HRH4ALDH1A1SMN1; SMN2TRIM24 | |
| SCHEMBL19547056 | 0.85 | HRH4 (0.55) | HRH4ALDH1A1KDM4E | |
| SCHEMBL1715756 | 0.85 | PIK3CA (0.57) | ALDH1A3ALDH1A1SMN1; SMN2KDM4EPIK3CA | |
| SCHEMBL23048714 | 0.81 | HRH3 (0.41) | HRH4ALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL23048878 | 0.81 | HRH3 (0.42) | — | |
| SCHEMBL23048648 | 0.81 | HRH3 (0.45) | HRH4ALDH1A1KDM4EMAPTLRRK2 | |
| SCHEMBL1914424 | 0.81 | MAPT (0.48) | HRH4ALDH1A1SMN1; SMN2TRIM24TRIM33 | |
| SCHEMBL11998350 | 0.81 | PTPN11 (0.43) | — | |
| SCHEMBL23048742 | 0.81 | PIK3CA (0.38) | ALDH1A3HRH4ALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4119561-A1 | HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS | Corcept Therapeutics Incorporated (US) | 2023-01-18 | — | — | EP | disclosed |
| EP-3851107-B1 | HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS | CORCEPT THERAPEUTICS INC (US) | 2022-10-19 | — | — | EP | disclosed |