⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL11167054 | 0.98 | — | — | |
| SCHEMBL3281539 | 0.79 | — | — | |
| SCHEMBL11297570 | 0.79 | ADRA2A (0.34) | — | |
| SCHEMBL14285754 | 0.76 | — | — | |
| SCHEMBL8143712 | 0.71 | — | — | |
| SCHEMBL10144891 | 0.71 | — | — | |
| SCHEMBL6878393 | 0.70 | — | — | |
| SCHEMBL7094563 | 0.68 | ADRA2A (0.47) | — | |
| SCHEMBL18671602 | 0.68 | NISCH (0.37) | — | |
| SCHEMBL9505880 | 0.67 | APOBEC3A (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4550169-A | ANTITUMOR AND ANTICARCINOGENIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1985-10-29 | — | — | US | claimed |
| EP-0146711-A2 | 2-hydrazino-1H-imidazoles | AMERICAN CYANAMID COMPANY (US) | 1985-07-03 | — | — | EP | claimed |
| US-7777032-B2 | N-4-[3-Chloro-4-(3-fluoro-benzyloxy)-phenyl]-N6-(3-ethyl-oxazolidin-2-ylidene)-quinazoline-4,6-diamine; use as type I receptor tyrosine kinase inhibitor; hyperproliferation diseases such as cancer; antiinflammatory agents | ARRAY BIOPHARMA INC. (US) | 2010-08-17 | — | — | US | disclosed |
| US-20090270621-A1 | QUINAZOLINE ANALOGS AS RECEPTOR TYROSINE KINASE INHIBITORS | ARRAY BIOPHARMA, INC. (US) | 2009-10-29 | — | — | US | disclosed |
| US-7585975-B2 | Quinazoline analogs as receptor tyrosine kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2009-09-08 | — | — | US | disclosed |
| US-7501427-B2 | Quinazoline analogs as receptor tyrosine kinase inhibitors | ARRAY BIOPHARMA, INC. (US) | 2009-03-10 | — | — | US | disclosed |
| US-20080194558-A1 | Quinazoline analogs as receptor Tyrosine Kinase inhibitors | ARRAY BIOPHARM, INC. (US) | 2008-08-14 | — | — | US | disclosed |
| US-20050101616-A1 | Quinazoline analogs as receptor tyrosine kinase inhibitors | ARRAY BIOPHARMA, INC. | 2005-05-12 | — | — | US | disclosed |
| US-20030232843-A1 | (1-Substituted-indol-3-yl) alkylidenehydrazinecarboximidamide derivatives as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2003-12-18 | — | — | US | disclosed |
| US-4550169-A | ANTITUMOR AND ANTICARCINOGENIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1985-10-29 | — | — | US | disclosed |