Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD38 | P28907 | 1/20 | 0.42 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 7/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.38 |
| ▸ | PIP4K2A | P48426 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24569809 | 1.00 | CD38 (0.42) | CD38EIF2AK2HTTMAPTMAPK1 | |
| SCHEMBL24569380 | 0.82 | EGFR (0.39) | CD38EIF2AK2HTTMAPTMAPK1 | |
| SCHEMBL29888199 | 0.82 | EGFR (0.39) | CD38EIF2AK2HTTMAPTMAPK1 | |
| SCHEMBL24569295 | 0.81 | ERBB2 (0.53) | EGFRERBB2 | |
| SCHEMBL24569631 | 0.79 | ERBB2 (0.41) | CD38HTTMAPTEGFRERBB2 | |
| SCHEMBL29888120 | 0.79 | ERBB2 (0.41) | CD38HTTMAPTEGFRERBB2 | |
| SCHEMBL24167316 | 0.78 | EGFR (0.57) | HTTMAPTMAPK1EGFRERBB2 | |
| SCHEMBL29888804 | 0.76 | EGFR (0.38) | CD38EIF2AK2HTTMAPTMAPK1 | |
| SCHEMBL24569933 | 0.76 | EGFR (0.38) | CD38EIF2AK2HTTMAPTMAPK1 | |
| SCHEMBL24569912 | 0.76 | KDM4E (0.58) | HTTMAPTMAPK1AHREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4267137-A1 | LACTAM (HETERO)ARYLFUSEDPYRIMIDINE DERIVATIVES AS INHIBITORS OF ERBB2 | Enliven Inc. (US) | 2023-11-01 | — | — | EP | disclosed |
| WO-2022140769-A1 | LACTAM (HETERO)ARYLFUSEDPYRIMIDINE DERIVATIVES AS INHIBITORS OF ERBB2 | ENLIVEN THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |