Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.67 |
| ▸ | CCR2 | P41597 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.33 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL306469 | 1.00 | CYP3A4 (0.67) | CYP3A4CCR2MAPTPOLBL3MBTL1 | |
| SCHEMBL306996 | 0.84 | CYP3A4 (0.44) | CYP3A4CCR2MAPTPOLBL3MBTL1 | |
| SCHEMBL10223041 | 0.83 | CYP3A4 (0.49) | CYP3A4CCR2MAPTPOLBL3MBTL1 | |
| SCHEMBL305891 | 0.83 | CYP3A4 (0.43) | CYP3A4CCR2MAPTPOLBL3MBTL1 | |
| SCHEMBL10222959 | 0.82 | CYP3A4 (0.46) | CYP3A4CCR2MAPTPOLBL3MBTL1 | |
| SCHEMBL12594242 | 0.82 | CYP3A4 (0.46) | CYP3A4CCR2MAPTPOLBL3MBTL1 | |
| SCHEMBL125827 | 0.82 | CYP3A4 (0.42) | CYP3A4CCR2MAPTPOLBL3MBTL1 | |
| SCHEMBL306497 | 0.81 | CYP3A4 (0.42) | CYP3A4CCR2MAPTPOLBL3MBTL1 | |
| SCHEMBL18707930 | 0.80 | CYP3A4 (0.52) | CYP3A4CCR2MAPTPOLBL3MBTL1 | |
| SCHEMBL170192 | 0.80 | CYP3A4 (1.00) | CYP3A4CCR2CYP2C9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11433061-B2 | Heteroaryl sulfonamides and CCR2/CCR9 | CHEMOCENTRYX, INC. (US) | 2022-09-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11433061-B2 | Heteroaryl sulfonamides and CCR2/CCR9 | CCR2, CCR9, CCR1 | CYP3A4 1934/4885CCR2 1/4885MAPT 4586/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.