Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 1/20 | 0.51 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.51 |
| ▸ | TDO2 | P48775 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.46 |
| ▸ | TNKS | O95271 | 3/20 | 0.46 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.45 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | CHUK | O15111 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | INSR | P06213 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29889598 | 0.89 | DYRK1A (0.56) | IL2MAP4K1TDO2DYRK1ATNKS | |
| SCHEMBL29888836 | 0.79 | RPS6KA3 (0.42) | IL2MAP4K1KCNH2MAP3K11IKBKB | |
| SCHEMBL28499630 | 0.75 | FLT3 (0.56) | IL2MAP4K1DYRK1AMAP3K11IKBKB | |
| SCHEMBL30376196 | 0.75 | MAP3K11 (0.66) | IL2MAP4K1DYRK1AKCNH2MAP3K11 | |
| SCHEMBL29652309 | 0.75 | DYRK1A (0.64) | DYRK1AFGFR3MAP3K11IKBKBCHUK | |
| Hydrochloric Acid SCHEMBL30313452 | 0.74 | MAP3K11 (0.65) | IL2MAP4K1DYRK1AKCNH2MAP3K11 | |
| SCHEMBL28502063 | 0.74 | CDK8 (0.52) | IL2MAP4K1DYRK1ATNKSMAP3K11 | |
| SCHEMBL12821883 | 0.71 | PIK3CA (0.49) | DYRK1AMAP3K11IKBKBCHUKABL1 | |
| SCHEMBL28506118 | 0.71 | DYRK1A (0.51) | MAP4K1DYRK1AMAP3K11IKBKBCHUK | |
| SCHEMBL29652377 | 0.71 | HRH4 (0.57) | DYRK1AMAP3K11IKBKBCHUKABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022171034-A1 | BICYCLIC COMPOUND AS HPK1 INHIBITOR AND APPLICATION THEREOF | 江苏先声药业有限公司 | 2022-08-18 | — | — | WO | disclosed |