Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.42 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29891665 | 1.00 | GPR119 (0.45) | GPR119SMN1; SMN2BRD3NTRK1PAK1 | |
| SCHEMBL22086326 | 1.00 | GPR119 (0.45) | GPR119SMN1; SMN2BRD3NTRK1PAK1 | |
| SCHEMBL22086319 | 1.00 | GPR119 (0.45) | GPR119SMN1; SMN2BRD3NTRK1PAK1 | |
| SCHEMBL29372092 | 1.00 | GPR119 (0.45) | GPR119SMN1; SMN2BRD3NTRK1PAK1 | |
| SCHEMBL29892095 | 1.00 | GPR119 (0.45) | GPR119SMN1; SMN2BRD3NTRK1PAK1 | |
| SCHEMBL16640393 | 0.91 | SMN1; SMN2 (0.45) | GPR119SMN1; SMN2BRD3PAK1HDAC1 | |
| SCHEMBL28620049 | 0.91 | SMN1; SMN2 (0.45) | GPR119SMN1; SMN2BRD3PAK1HDAC1 | |
| SCHEMBL4029062 | 0.88 | GSK3B (0.43) | GPR119SMN1; SMN2BRD3PAK1HDAC1 | |
| SCHEMBL4029061 | 0.88 | GSK3B (0.43) | GPR119SMN1; SMN2BRD3PAK1HDAC1 | |
| Hydrochloric Acid SCHEMBL14335191 | 0.87 | GSK3B (0.44) | GPR119SMN1; SMN2BRD3PAK1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313295-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 19 (USP19) | Almac Discovery Limited (GB) | 2024-02-07 | — | — | EP | disclosed |
| WO-2022200523-A1 | PHARMACEUTICALS COMPOUNDS AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 19 (USP19) | ALMAC DISCOVERY LIMITED (GB) | 2022-09-29 | — | — | WO | disclosed |